The levonorgestrel-releasing intrauterine system 52 mg as a contraceptive versus a therapeutic: essential differences and perspectives: The European Journal of Contraception & Reproductive Health Care: Vol 0, No 0
Abstract
Background
It has been 100 years since the discovery of estrogen and almost that since the discovery of progesterone. It has been more than 50 years since the concept of using intrauterine progesterone. Ten years after its synthesis, research using levonorgestrel as an intrauterine agent was introduced.
Areas covered
The pharmacodynamics and pharmacokinetics of the LNG-IUS and the LNG-IUS 52 mg specifically explain why intrauterine LNG is so effective for contraception. When intrauterine LNG is used therapeutically it should ideally be based on clinical monitoring of the pathology being treated rather than a fixed period of time. While the LNG-IUS 52 mg is likely to be necessary for most medical conditions , the use of LNG-IUS 13.5 mg should be considered for hyperplasia and endometrial protection during estrogen therapy and for elderly women who are more susceptible to low-rate LNG-induced breast cancer, although there is no official indication for this yet.
Conclusion
The desire for fertility control, therapy for various genital pathological conditions and reduction of recurrent endometrial decidualization and inflammatory breakdown and its consequences, and menopausal problems can be helped by intrauterine LNG. This review explains how a contraceptive became an important WHO-listed drug.
SHORT CONDENSATION
There are significant differences on many levels in the use of intrauterine levonorgestrel for contraception compared to its therapeutic use.
Disclosure statement
The author reports no potential conflict of interest.
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